gabapentin and diclofenac reduce opioid consumption in patients undergoing tonsillectomy: a result of altered cns drug delivery?

Gabapentin and Diclofenac Reduce Opioid Consumption in Patients Undergoing Tonsillectomy: A Result of Altered CNS Drug Delivery?

Implication for health policy/practice/research/medical education: Our letter highlights the role of CNS drug delivery mechanisms on the efficacy of opioid pharmacotherapy. Information presented in this letter emphasizes the importance of translational studies aimed at understanding specific mechanisms involved in CNS opioid delivery, opioid efficacy, and/or drug-opioid interactions. Copyright ...

Analgesic Effects of Gabapentin and Diclofenac on Post-Operative Pain in Patients Undergoing Tonsillectomy

We studied the article by Yeganeh Mogadam et al. (1) with great interest, “comparison of analgesic effect between gabapentin and diclofenac on Post-Operative Pain in Patients Undergoing Tonsillectomy”. The authors had demonstrated that administration of preoperative gabapentin and diclofenac significantly reduced postoperative pain, and the amount of opioid consumption. Although the article was...

Comparison of Analgesic Effect Between Gabapentin and Diclofenac on Post-Operative Pain in Patients Undergoing Tonsillectomy

BACKGROUND Tonsillectomy is a common procedure causing considerable postoperative pain. Postoperative pain intensity of 60 - 70 in the scale of visual analog scale (VAS) has been reported up to 3 - 4 days which could continue until 11 days after the surgery. OBJECTIVES The current study aimed to compare the analgesic effect of gabapentin and diclofenac on pain after tonsillectomy with the con...

Comparison of Analgesic Effect between Gabapentin and Diclofenac on Post-Operative Pain in Patients Undergoing Tonsillectomy

Dear Editor, We have examined attentively the latest manuscript by Yeganeh Mogadam et al. entitled " Comparison of Analgesic Effect between Gabapentin and Diclofenac on Post-Operative Pain in Patients Undergoing Tonsillectomy " available in Archives of Trauma Research (1). Ninety patients were included to receive 20 mg/kg oral gabapentin (n = 30), 1.0 mg/kg rectal diclofenac (n = 30) or placebo...

Comparison of Analgesic Effect between Gabapentin and Diclofenac on Post-Operative Pain in Patients Undergoing Tonsillectomy

Implication for health policy/practice/research/medical education: This is a brief comment on the very interesting comparative effectiveness study of gabapentin and diclofenac on pain after tonsillectomy. Copyright © 2013, Kashan University of Medical Sciences; License Kowsar Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://crea...

analgesic effects of gabapentin and diclofenac on post-operative pain in patients undergoing tonsillectomy